Prof FENG Bo 馮波
PhD
Rm 105A, Lo Kwee Seong Integrated Biomedical Sci. Bldg, CUHK
  39431455
 fengbo@cuhk.edu.hk
 http://www.sbs.cuhk.edu.hk/Feng_Bo/  
 
   
   
 
 Research Interests
 
1. 
Conversion of somatic cells to pluripotent stem cells
   
2. 
Discovery of new reprogramming factors
   
3. 
Gene regulation for the maintenance and reinstatement of stem cell identity
   
4. 
Generation of clinical grade stem cells (iPS)
   
5. 
Tissue regeneration
   
 
 Publications
 
1.
Hu J, Lei Y, Wong WK, Liu S, Lee KC, He X, You W, Zhou R, Guo JT, Chen X, Peng X, Sun H, Huang H, Zhao H, Feng B (2014), Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors,  Nucleic Acids Res. (2014 Feb 5)[Epub ahead of print]
   
2.
Lu, X., Goke, J., Sachs, F., Jacques, P.E., Liang, H., Feng, B., Bourque, G., Bubulya, P.A. & Ng, H.H (2013), SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells, Nat Cell Biol 15, 1141-1152
   
3.
Tsang WH, Wang B, Wong WK, Shi S, Chen X, He X, Gu S, Hu J, Wang C, Liu PC, Lu G, Chen X, Zhao H, Poon WS, Chan WY, Feng B (2013), LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment, Stem Cell Res. 2013 Aug 2;11(3):1091-1102
   
4.
Chan YS, Göke J, Lu X, Venkatesan N, Feng B., Su IH, Ng HH (2012), PRC2 Dependent Repressive role of PRDM14 in Human Embryonic Stem Cells and iPSC Reprogramming, Stem Cells. 31, 682-92
   
5.
Chia NY*, Chan YS*, Feng B*, Lu X, Orlov YL, Moreau D, Kumer P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F and Ng HH (2010), A genome-wide RNAi screen reveals determinants of human ES cell identity, Nature 468; 11 (2): 316–320 (*Co-first authors)
   
6.
Heng JC*, Feng B*, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B and Ng HH (2010), The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells, Cell Stem Cell 5;6(2):167-74. (*Co-first authors)
   
7.
Feng B, Ng JH, Heng JC and Ng HH (2009), Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells, Cell Stem Cell. 3;4(4):301-12. Review.
   
8.
Feng B, Jiang J, Kraus P, Ng JH, Heng JC, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T and Ng HH (2009), Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb, Nat Cell Biol. 11(2):197-203
   
9.
Feng B, Bulchand S, Yaksi E, Friedrich RW and Jesuthasan S (2005), The recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection, BMC Neurosci. 6: 46
   
10.
Feng B, Schwarz H and Jesuthasan S (2002), Furrow-specific endocytosis during cytokinesis of zebrafish blastomeres, Exp Cell Res. 279(1): 14-20
   
   
Copyright © 2009 School of Biomedical Sciences. The Chinese University of Hong Kong.