Prof LEE Ka Ho Kenneth 李嘉豪
B.Sc., PhD., C.Biol., M.I.Biol.
Rm 126A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, CUHK
  39436785
 kaholee@cuhk.edu.hk
 
 
   
   
 
 Research Interests
 
1. 
Application of Small Molecules in Stem Cell Biology
   
2. 
Use of Small Molecules in the treatment of Liver fibrosis and heart diseases
   
3. 
Role of BRE gene in HUCPV stem cell biology
   
 
 Publications
 
1.
He YQ, Li Y, Wang XY, He XD, Li J, Chuai M, Lee KKH, Wang J, Wang LJ & Yang X (2014), Dimethyl phenyl piperazine iodide (DMPP) induces glioma regression by inhibiting angiogenesis, Experimental Cell Research 320 (2): 354-364.
   
2.
Lam KH, Gambari R, Lee KKH , ChenYX, Kok SHL, Wong RSM, Lau FYL, Cheng CH, Wong WY, Bian ZA, Chan SC, Tang JOC & Chui CH (2014), Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus, Bioorganic & Medicinal Chemistry Letters 24(1): 367-370.  Bioorganic & Medicinal Chemistry Letters 24(1): 367-370.
   
3.
Chui YL, Ma CH, Li W, Xu Z, Yao Y, Lin KY, Chan JYH & Lee KKH (2014), Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells, Apoptosis 19(5): 829-840.
   
4.
Lam PL, Lu GL, Hon KM, Lee KW, Ho CL, Wang X, Tang JCO, Lam KH, WongRSM, Kok SHL, Bian Z, Li H, Lee KKH, Gambari R, Chui CH & Wong RWY (2014), Development of ruthenium (II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus, Dalton Transactions 43:3949-3957.
   
5.
Wang XY, Li Y, Wang G, Wang LJ, Münsterberg A, Chuai M, Lee KK, Geng JG & Yang X (2014), Combinational electroporation and transplantation approach of studying gene functions in avian embryos, Chinese Science Bulletin 59(7): 616-624.
   
6.
Lam KH, Lee KKH, Gambari R, Kok SHL, Kok TW, Chan A SC, Bian ZX, Wong WY, Wong RSM, Lau FY, Tong SW, Chan KW, Cheng CH & Chui CH (2014). Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue, Phytomedicine 21: 877-882.
   
7.
Lam PL, Lee KKH, Ho YW, Wong RSM, Tong -W, Cheng CH, Lam KH, Tang JCO, Bain Z-X, Gambari R, Kok SHL & Chui CH (2014), Development of chitosan based microcapsules as a delivery vehicle for orally administered daunorubicin, RSC Advances 4:14109-14114.
   
8.
Cheng X, Wang G, Lee KKH & Yang X (2014), Dexamethasone use during pregnancy: potential adverse effects on embryonic skeletogenesis, Current Pharmaceutical Design DOI: 10.2174/1381612820666140205144534 [Epub ahead of print].
   
9.
Li Y, Pang I, Wang X-Y, Chuai M, Münsterberg A, Lee KK & Yang X (2014), Endoderm contributes to endocardial composition during cardiogenesis, Chinese Science Bulletin 59(22): 2749–2755.
   
10.
Zhao BY, Liao ZF, Chen S, Yuan ZQ, Chen YL, Lee KKH, Qi XF, Shen XT, Zheng X, Quinn T & Cai DQ (2014). Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rat,  Journal of Cellular and Molecular Medicine 8(5): 780-789.
   
11.
Ma ZL, Wang G, Cheng X, Chuai M, Kurihara H, Lee KKH & Yang X (2014), Excess caffeine exposure impairs eye development during chick embryogenesis, Journal of Cellular and Molecular Medicine 18(6): 1134-1143.
   
12.
Lam PL, Kok SHL, Bian ZX, Lam KH, Tang JCO, Lee KKH*, Gambari R* & Chui CH* (2014), D-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery, Colloids and Surfaces B: Biointerfaces 117: 277-283 (*co-corresponding author)
   
13.
Chan RYK, Lee KKH, Wong WY, Tang JCO, Lam KH, Cheng CH, Lau FY, Kok SHL, Gambari R & ChuiCH (2014), The puzzling issue of “vehicle-treated control” when using ethanol as drug carrier for MCF-7 cells. Phytotherapy Research 28(11):1735-1736
   
14.
Tang MK, Lo LM, Shi WT, Yao Y, Lee HSS & Lee KKH (2014), Transient acid treatment cannot induce neonatal somatic cells to become pluripotent stem cells, F1000Research 3:102 (DOI: 10.12688/f1000research.4382).
   
15.
Chen Y, Wang G, Ma Z-L, Li Y, Wang X-Y, Cheng X, Chuai M, Lee KKH* & Yang X* (2014), Adverse effects of high glucose levels on somite and limb development in avian embryos. Food and Chemical Toxicology 71: 1-9. (*co-corresponding author),  Food and Chemical Toxicology 71: 1-9. (*co-corresponding author).
   
16.
Lam P-L, Kok SHL, Bian Z-X, Lam K-H, Gambari R, Lee KKH & Chui C-H (2014), Microencapsulation-protected L-ascorbic acid for the application of human epithelial HaCaT cell proliferation,  Journal of Microencapsulation 31(8):754-8.
   
17.
Li Y, Wang G, Lao P, Chuai M, Lee KKH, Liu C and Yang X (2014), Autophagy functions on EMT in gastrulation of avian embryo, Cell Cycle 13(17): 2752-2762
   
18.
Li Y, Wang X-Y, Zhang Z-L, Cheng X, Li X-D, Chuai M, Lee KKH, Kurihara H & Yang X (2014), Excess ROS induced by AAPH leads to myocardial hypertrophy during heart development, International Journal of Cardiology 176(1): 62-73.
   
19.
Qi C-L, Zhou Q, Li B, Yang Y, Cao L, Ye Y, Li J-C, Ding Y, Wang H, Wang J, He X-D,Zhang Q-Q , Lan T, Lee KKH, Li W, Song X, Zhou J and Yang X (2014), Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis, Oncotarget 5(20):9966-9979.  Oncotarget 5(20):9966-9979.
   
20.
Cheng X, Chen J-L, Ma Z-L, Zhang Z-L, Lu S, Mai D-M, Liu J-J, Chuai M, Lee KKH, Wan C and Yang X. (2014), Biphasic influence of dexamethasone exposure on embryonic vertebrate skeleton development, Toxicology and Applied Pharmacology 281(1):19-29.
   
   
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