Prof. Huang Yu, Associate Director (External Links) of the School of Biomedical Sciences (SBS), together with his research team members, Dr. Wang Li and Dr. Luo Jiang-Yun, received the First-class award in Natural Sciences under the Higher Education Outstanding Scientific Research Output Award (Science and Technology) 2019 from the Ministry of Education (MoE), China. The awarded project investigates the new role of “Hippo signalling pathway” in atherosclerosis caused by turbulent blood flow.

This study conducted by Prof. Huang’s team in collaboration with Tianjin Medical University found that the occurrence of vascular inflammation by inhibiting the “Hippo signalling pathway” of the vascular endothelium leads to development of atherosclerosis. Further study found that statins commonly used in clinical practice to lower blood lipid level can activate the “Hippo signalling pathway” and it is expected that new drugs for atherosclerotic vascular diseases can be developed by searching for activators of the “Hippo signalling pathway”. The team has established a drug screening platform targeting the Hippo pathway and several compounds that have a relatively stronger stimulatory effect on this pathway have been obtained through preliminary screening. The therapeutic effects of some drugs are currently being verified on mouse models.

We sincerely congratulate Prof. Huang, Dr. Wang and Dr. Luo on their remarkable accomplishments and wish them continued success in their research endeavors in the future.

The related coverage by the Communications and Public Relations Office, CUHK can be viewed HERE.

香港中文大學生物醫學學院副院長（對外事務）黃聿教授、與其研究團隊成員王力博士及駱江云博士，獲頒國家教育部頒授2019年度高等學校科學研究優秀成果獎（科學技術）自然科學獎一等獎，該獲獎的項目研究Hippo信號通路在湍流引起的動脈粥樣硬化中的新作用。

本學院黃聿教授團隊與天津醫科大學的合作研究發現，抑制血管內皮的「Hippo信號通路」會促進血管炎症發生，進而導致動脈粥樣硬化，而臨床上常用來降低血脂的他汀類藥物可顯著啟動Hippo通路，有望通過尋找「Hippo信號通路」的激動劑找到治療動脈粥樣化的新藥。團隊目前已經建立針對「Hippo信號通路」為靶點的藥物篩選平台，並已初步篩選出幾個對「Hippo信號通路」啟動作用比較強的化合物，目前正在小鼠模型上驗證治療效果。

我們衷心祝賀黃教授、王博士及駱博士榮獲此項殊榮，並祝願他們在日後的學術研究上繼續取得成功。

中大傳訊及公共關係處的有關報導請按此處瀏覽。

香港中文大学生物医学学院副院长（对外事务）黄聿教授、与其研究团队成员王力博士及骆江云博士，获颁国家教育部颁授2019年度高等学校科学研究优秀成果奖（科学技术）自然科学奖一等奖，该获奖的项目研究Hippo信号通路在湍流引起的动脉粥样硬化中的新作用。

本学院黄聿教授团队与天津医科大学的合作研究发现，抑制血管内皮的「Hippo信号通路」会促进血管炎症发生，进而导致动脉粥样硬化，而临床上常用来降低血脂的他汀类药物可显著启动Hippo通路，有望通过寻找「Hippo信号通路」的激动剂找到治疗动脉粥样化的新药。团队目前已经建立针对「Hippo信号通路」为靶点的药物筛选平台，并已初步筛选出几个对「Hippo信号通路」激活作用比较强的化合物，目前正在小鼠模型上验证治疗效果。

我们衷心祝贺黄教授、王博士及骆博士荣获此项殊荣，并祝愿他们在日后的学术研究上继续取得成功。

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